Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

MAT Acosta, BD Singer - European Respiratory Journal, 2020 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

COVID-19: pandemic risk, resilience and possibilities for aging research

A Wister, M Speechley - Canadian Journal on Aging/La revue …, 2020 - cambridge.org
The COVID-19 global crisis is reshaping Canadian society in unexpected and profound
ways. The significantly higher morbidity and mortality risks by age suggest that this is largely …

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

M Ogrodnik, H Salmonowicz, VN Gladyshev - Aging cell, 2019 - Wiley Online Library
Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia

N Lv, Y Zhao, X Liu, L Ye, Z Liang, Y Kang, Y Dong… - Aging …, 2022 - Wiley Online Library
Disproportionately high incidence and mortality of respiratory infection such as influenza A
virus (IAV) and SARS‐CoV‐2 have been evidenced in the elderly, but the role and the …

Cellular senescence in age-related disorders

J Kaur, JN Farr - Translational Research, 2020 - Elsevier
Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Endothelial senescence and chronic fatigue syndrome, a COVID-19 based hypothesis

A Sfera, C Osorio… - Frontiers in Cellular …, 2021 - frontiersin.org
Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown
etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep …

The right time for senescence

D Paramos-de-Carvalho, A Jacinto, L Saúde - Elife, 2021 - elifesciences.org
Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

Cellular senescence: a view throughout organismal life

C von Kobbe - Cellular and molecular life sciences, 2018 - Springer
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …

Durability of SARS-CoV-2–specific T-cell responses at 12 months postinfection

Z Lu, ED Laing, J Pena DaMata… - The Journal of …, 2021 - academic.oup.com
Background Characterizing the longevity and quality of cellular immune responses to severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of …

Cellular and molecular biomarkers of long COVID: a scoping review

E Espín, C Yang, CP Shannon, S Assadian, D He… - …, 2023 - thelancet.com
Summary Background Long-COVID (LC) encompasses diverse symptoms lasting months
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …