Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

YI Kim, KM Yu, JY Koh, EH Kim, SM Kim, EJ Kim… - Nature …, 2022 - nature.com
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly
among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 …

The conundrum of human immune system “senescence”

G Pawelec, A Bronikowski, SC Cunnane… - Mechanisms of ageing …, 2020 - Elsevier
There is a great deal of debate on the question of whether or not we know what ageing is
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …

Cellular senescence in aging and age-related disease: from mechanisms to therapy

BG Childs, M Durik, DJ Baker, JM Van Deursen - Nature medicine, 2015 - nature.com
Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

T cells: warriors of SARS-CoV-2 infection

P de Candia, F Prattichizzo, S Garavelli… - Trends in …, 2021 - cell.com
Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is
characterized by massive cytokine release and T cell loss. The exaggerated host immune …

[HTML][HTML] COVID-19 severity is predicted by earlier evidence of accelerated aging

CL Kuo, LC Pilling, JL Atkins, JAH Masoli, J Delgado… - Medrxiv, 2020 - ncbi.nlm.nih.gov
With no known treatments or vaccine, COVID-19 presents a major threat, particularly to older
adults, who account for the majority of severe illness and deaths. The age-related …

Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome

RC Borges, MS Hohmann… - International Reviews of …, 2021 - Taylor & Francis
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This novel coronavirus
emerged in China, quickly spreading to more than 200 countries worldwide. Although most …

Severe COVID-19 lung infection in older people and periodontitis

R Aquino-Martinez, S Hernández-Vigueras - Journal of Clinical Medicine, 2021 - mdpi.com
Periodontal bacteria dissemination into the lower respiratory tract may create favorable
conditions for severe COVID-19 lung infection. Once lung tissues are colonized, cells that …

Long COVID and older people

V Mansell, SH Dykgraaf, M Kidd… - The lancet Healthy …, 2022 - thelancet.com
Long COVID is a poorly understood condition, with a wide spectrum of effects on multiple
body systems and variable presentation in different individuals. Long COVID is of particular …

The impact of immuno-aging on SARS-CoV-2 vaccine development

J Connors, MR Bell, J Marcy, M Kutzler, EK Haddad - Geroscience, 2021 - Springer
The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3
million deaths as of November 2020. This infection has proved more deadly to older adults …

Dissecting primary and secondary senescence to enable new senotherapeutic strategies

TD Admasu, MJ Rae, A Stolzing - Ageing Research Reviews, 2021 - Elsevier
Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …