[HTML][HTML] The bright side of reactive oxygen species: lifespan extension without cellular demise

K Maiese - Journal of translational science, 2016 - ncbi.nlm.nih.gov
Oxidative stress and the generation of reactive oxygen species (ROS) can lead to
mitochondrial dysfunction, DNA damage, protein misfolding, programmed cell death with …

The good, the bad, and the ugly of ROS: new insights on aging and aging‐related diseases from eukaryotic and prokaryotic model organisms

AL Santos, S Sinha, AB Lindner - Oxidative medicine and …, 2018 - Wiley Online Library
Aging is associated with the accumulation of cellular damage over the course of a lifetime.
This process is promoted in large part by reactive oxygen species (ROS) generated via …

[HTML][HTML] Role of mitochondrial reverse electron transport in ROS signaling: potential roles in health and disease

F Scialò, DJ Fernández-Ayala, A Sanz - Frontiers in physiology, 2017 - frontiersin.org
Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to
be the main cause of aging and age-related diseases including cancer, diabetes and …

[HTML][HTML] Mitochondrial management of reactive oxygen species

G Napolitano, G Fasciolo, P Venditti - Antioxidants, 2021 - mdpi.com
Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Mitochondria‐ros crosstalk in the control of cell death and aging

S Marchi, C Giorgi, JM Suski… - Journal of signal …, 2012 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

[HTML][HTML] Aging hallmarks and the role of oxidative stress

E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

[HTML][HTML] Six functions of respiration: Isn't it time to take control over ROS production in mitochondria, and aging along with it?

VP Skulachev, MY Vyssokikh, BV Chernyak… - International Journal of …, 2023 - mdpi.com
Cellular respiration is associated with at least six distinct but intertwined biological
functions.(1) biosynthesis of ATP from ADP and inorganic phosphate,(2) consumption of …

Role of ROS and RNS sources in physiological and pathological conditions

S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

[PDF][PDF] Interplay between oxidative stress and metabolism in signalling and disease

A Trostchansky, C Quijano, H Yadav… - … Medicine and Cellular …, 2016 - researchgate.net
It is well recognized that energy metabolism is linked to the production of reactive species
and critical enzymatic processes allied to metabolic pathways can be affected by redox …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …