Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Many have criticized the amyloid cascade hypothesis of Alzheimer's disease for its
inconsistencies and failures to either accurately predict disease symptoms or guide the …

Alzheimer's disease (AD) is the most common form of dementia, which affects more than 35
million people worldwide with increasing tendency. Satisfying therapies and prevention are …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and
effective treatments against it remain elusive. The hypothesis that amyloid-β (Aβ) peptides …

Few diagnoses in modern medicine evoke more apprehension in patients and their families
than Alzheimer disease (AD). Defined as a clinical and pathological entity a century ago, the …

It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …

The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the
pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD) …

Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …

The inability to effectively halt or cure Alzheimer's disease (AD), exacerbated by the recent
failures of high-profile clinical trials, emphasizes the urgent need to understand the complex …