Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …

Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents' survival, we …

Human longevity and healthy aging show moderate heritability (20%–50%). We conducted
a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for …

Many epidemiological data indicate the presence of a strong familial component of longevity
that is largely determined by genetics, and a number of possible associations between …

Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …

The exceptional longevity of centenarians is due in part to inherited genetic factors, as
deduced from data that show that first degree relatives of centenarians live longer and have …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

Approximately one-quarter of the variation in lifespan in developed countries can be
attributed to genetic factors. However, even large population based studies investigating …

In genome-wide association studies (GWAS) of complex traits, single SNP analysis is still
the most applied approach. However, the identified SNPs have small effects and provide …