While polygenic risk scores (PRSs) are poised to be translated into clinical practice through
prediction of inborn health risks, a strategy to utilize genetics to prioritize modifiable risk …

The enormous variation in human lifespan is in part due to a myriad of sequence variants,
only a few of which have been revealed to date. Since many life-shortening events are …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that …

Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs;
however, its molecular mechanisms are poorly understood. Here, we use multi-omic …

The lack of a formal definition of human longevity continues to generate confusion about its
genetic and nongenetic determinants. In order to characterize how differences in birth year …

Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …

In no species other than humans do cultural, social, and biological factors interact with each
other in modulating complex phenotypes. Thus, the identification of genetic factors that affect …

Here we explore association with human longevity of common genetic variation in three
major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair …

Background Identification of genes that modulate longevity is a major focus of aging-related
research and an area of intense public interest. In addition to facilitating an improved …