Molecular genetics of Alzheimer's disease: the role of β-amyloid and the presenilins

A Tandon, E Rogaeva, M Mullan… - Current Opinion in …, 2000 - journals.lww.com
Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

Genetics and the dementia patient

LA Farrer - The Neurologist, 1997 - journals.lww.com
BACKGROUND: Alzheimer's disease (AD) is a common fatal neurodegenerative disorder for
which there is no effective treatment or cure. The biological basis of AD is poorly understood …

The genetics of Alzheimer disease: current status and future prospects

D Blacker, RE Tanzi - Archives of Neurology, 1998 - jamanetwork.com
Four genes involved in the development of Alzheimer disease have been identified. Three
fully penetrant (deterministic) genes lead to the development of Alzheimer disease in …

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

Molecular genetics of Alzheimer's disease

PH St George-Hyslop - Biological psychiatry, 2000 - Elsevier
Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

[HTML][HTML] Molecular biology and genetics of Alzheimer's disease

PH St George-Hyslop, A Petit - Comptes rendus biologies, 2005 - Elsevier
Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a
multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have …

Genes and susceptible loci of Alzheimer's disease

BS Shastry, FJ Giblin - Brain research bulletin, 1999 - Elsevier
Alzheimer's disease (AD) is the most common and devastating neurodegenerative disease
of the elderly. Many research findings on familial AD suggest that the mechanisms of the …

Genetic risk factors in familial Alzheimer's disease

S Sorbi, P Forleo, A Tedde, E Cellini, M Ciantelli… - Mechanisms of ageing …, 2001 - Elsevier
In the last 10 years significant progress has been made to describe and identify the
underlying biological mechanisms that cause the different manifestation of Alzheimer's …

Molecular genetics of Alzheimer disease

PH St George-Hyslop - Seminars in neurology, 1999 - thieme-connect.com
Epidemiological and individual case studies indicate that genetic factors play a significant
role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families …

Alzheimer's disease: clinical molecular genetics

J Hardy - Clinics in geriatric medicine, 1994 - Elsevier
Alzheimer's disease (AD) is the major cause of dementia in the elderly, and it afflicts a high
proportion of the population over 70 years of age. Until recently, there was no known cause …