Transcriptional regulation and its misregulation in Alzheimer's disease

XF Chen, Y Zhang, H Xu, G Bu - Molecular brain, 2013 - Springer
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss
of memory and cognitive function. A key neuropathological event in AD is the accumulation …

Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility

J Theuns, C Van Broeckhoven - Human molecular genetics, 2000 - academic.oup.com
In recent years, important progress has been made in uncovering genes implicated in
Alzheimer's disease (AD). Three causal genes have been identified in which mutations …

Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker?

JH Lee, H Ryu - BMB reports, 2010 - koreascience.kr
Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder
and shows progressive memory loss and cognitive decline. Intraneuronal filaments …

Genes associated with Alzheimer's disease: an overview and current status

M Giri, M Zhang, Y Lü - Clinical interventions in aging, 2016 - Taylor & Francis
Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Etiology of Alzheimer's Disease.

C Zhang - Discovery Medicine, 2023 - europepmc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary
cause of dementia in the elderly. The research on AD has markedly evolved since …

Transcriptional and Post-Transcriptional Regulations of Amyloid-β Precursor Protein (APP) mRNA

K Sato, K Takayama, M Hashimoto, S Inoue - Frontiers in Aging, 2021 - frontiersin.org
Alzheimer's disease (AD) is an age-associated neurodegenerative disorder characterized
by progressive impairment of memory, thinking, behavior, and dementia. Based on ample …

Advances in genetics and epigenetic alterations in Alzheimer's disease: a notion for therapeutic treatment

R Rabaneda-Bueno, B Mena-Montes, S Torres-Castro… - Genes, 2021 - mdpi.com
Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term
functional and cognitive impairment and greatly reduces life expectancy. Early genetic …

Advances in genetic and molecular understanding of Alzheimer's disease

L Ibanez, C Cruchaga, MV Fernández - Genes, 2021 - mdpi.com
Alzheimer's disease (AD) has become a common disease of the elderly for which no cure
currently exists. After over 30 years of intensive research, we have gained extensive …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

The epigenetics of Alzheimer's disease: factors and therapeutic implications

X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …