Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as
a hallmark of cancer development and progression. However, locus-specific difference of …

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

Background DNA methylation is an important epigenetic modification, associated with gene
expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks …

Abstract Changes in DNA methylation, whether hypo‐or hypermethylation, have been
shown to be associated with the progression of colorectal cancer. Methylation changes …

ABSTRACT DNA methylation is recognized as one of several epigenetic regulators of gene
expression and as potential driver of carcinogenesis through gene-silencing of tumor …

DNA methylation analysis methods have undergone an impressive revolution over the past
15 years. Regarding colorectal cancer (CRC), the localization and distribution of several …

Recent studies show that colorectal cancer is strongly associated with aberrant DNA
methylation, which has been linked to the origin and progression of the disease. This fact …

The identification of genes that are differentially methylated in colorectal cancer (CRC) has
potential value for both diagnostic and therapeutic interventions specifically in high-risk …

The aims were to profile the DNA methylation in colorectal cancer (CRC) and to explore
cancer-specific methylation biomarkers. Fifty-four pairs of CRCs and the adjacent normal …

DNA methylation exerts critical effects on gene-expression regulation in normal cells, and
alterations on the normal methylation patterns characterize, and likely contribute, to cancer …