Highlights•Immunosenescence leads to increased susceptibility to infection and decreased
vaccine response.•Heme-oxygenase gene expression may be an important element in age …

Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …

Immunosenescence is described as a decline in the normal functioning of the immune
system associated with physiologic ageing. Immunosenescence contributes to reduced …

At first glance, longevity and immunity appear to be different traits that have not much in
common except the fact that the immune system promotes survival upon pathogenic …

The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Aging population demographics, combined with suboptimal vaccine responses in the
elderly, make the improvement of vaccination strategies in the elderly a developing public …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …