Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

The goal of annual influenza vaccination is to reduce mortality and morbidity associated with
this disease through the generation of protective immune responses. The objective of the …

Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …

Immunosenescence refers to the inability of an aging immune system to produce an
appropriate and effective response to challenge. This immune dysfunction may manifest as …

With increasing age, the ability of the adaptive immune system to respond to vaccines and to
protect from infection declines. In parallel, the production of inflammatory mediators …

The increasing ratio of ageing population poses new challenges to healthcare systems. The
elderly frequently suffer from severe infections. Vaccination could protect them against …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …