Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease

Y Lin, DF Postma, LS Steeneken… - Aging …, 2023 - Wiley Online Library
Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to
an incomplete understanding of virus pathogenesis and heterogeneity among patients …

Outcomes from COVID-19 across the range of frailty: excess mortality in fitter older people

A Miles, TE Webb, BC Mcloughlin, I Mannan… - European geriatric …, 2020 - Springer
Purpose Our aim was to quantify the mortality from COVID-19 and identify any interactions
with frailty and other demographic factors. Methods Hospitalised patients aged≥ 70 were …

COVID-19: a challenge to physiology of aging

AG Golubev - Frontiers in physiology, 2020 - frontiersin.org
The death toll of the current COVID-19 pandemic is strongly biased toward the elderly.
COVID-19 case fatality rate (CFR) increases with age exponentially, its doubling time being …

Age-related changes in plasma biomarkers and their association with mortality in COVID-19

EHA Michels, B Appelman… - European …, 2023 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …

Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults

L Lengelé, M Locquet, M Moutschen… - Aging clinical and …, 2022 - Springer
Background The identification of coronavirus disease 2019 (COVID-19) risk factors is
requested to implement prevention strategies. Aim To explore the associations between the …

Implications of frailty in COVID-19

C Lee, WH Frishman - Cardiology in Review, 2021 - journals.lww.com
As the global coronavirus disease-19 (COVID-19) pandemic caused by severe acute
respiratory distress syndrome coronavirus 2 continues to cause higher mortality and …

[HTML][HTML] Are older people really more susceptible to SARS-CoV-2?

S Zhang, Z Yang, ZN Li, ZL Chen, SJ Yue… - Aging and …, 2022 - ncbi.nlm.nih.gov
Since the outbreak, COVID-19 has spread rapidly across the globe due to its high infectivity
and lethality. Age appears to be one of the key factors influencing the status and progression …

Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using …

RK Owen, SP Conroy, N Taub, W Jones… - Age and …, 2021 - academic.oup.com
Background The aim of this study was to describe outcomes in hospitalised older people
with different levels of frailty and COVID-19 infection. Methods We undertook a single-centre …

Frailty and comorbidity in predicting community COVID‐19 mortality in the UK Biobank: the effect of sampling

JKL Mak, R Kuja‐Halkola, Y Wang… - Journal of the …, 2021 - Wiley Online Library
Abstract Background/Objectives Frailty has been linked to increased risk of COVID‐19
mortality, but evidence is mainly limited to hospitalized older individuals. This study aimed to …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …