Immune infiltration of ulcerative colitis and detection of the m6A subtype

C Gu, J Wu, W Zhang, Y Yao, W Yan… - Journal of …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent colon
inflammation. N6‐methyladenosine (m6A) methylation is one of the most prevalent RNA …

A broad m6A modification landscape in inflammatory bowel disease

K Nie, J Yi, Y Yang, M Deng, Y Yang… - Frontiers in cell and …, 2022 - frontiersin.org
Background and Aims: N6-Methyladenosine (m6A) is the most common post-transcriptional
modification on eukaryotic mRNA, affecting the mRNA's fate. The role of m6A regulation in …

The emerging clinical application of m6A RNA modification in inflammatory bowel disease and its associated colorectal cancer

X Xu, J Huang, DKW Ocansey, Y Xia… - Journal of …, 2021 - Taylor & Francis
Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most
widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) …

Implication of m6A mRNA methylation in susceptibility to inflammatory bowel disease

M Sebastian-delaCruz, A Olazagoitia-Garmendia… - Epigenomes, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that develops due to the interaction between genetic and environmental factors. More …

RNA methylation machinery and m6A target genes as circulating biomarkers of ulcerative colitis and Crohn's disease: Correlation with disease activity, location, and …

TK Motawi, OG Shaker, G Amr, MA Senousy - Clinica Chimica Acta, 2024 - Elsevier
Accurate diagnosis of ulcerative colitis (UC) and Crohn's disease (CD), the main subtypes of
inflammatory bowel disease (IBD), has been challenging due to the constraints of the current …

Epigenetic modification of m6A methylation: Regulatory factors, functions and mechanism in inflammatory bowel disease

Y Wang, C Chen, W Yan, Y Fu - The International Journal of Biochemistry & …, 2024 - Elsevier
Although the exact cause of inflammatory bowel disease (IBD) is still unknown, there is a lot
of evidence to support the notion that it results from a combination of environmental factors …

[HTML][HTML] m6A modification in inflammatory bowel disease provides new insights into clinical applications

J Zhang, B Song, Y Zeng, C Xu, L Gao, Y Guo… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …

[HTML][HTML] A new model of spontaneous colitis in mice induced by deletion of an RNA m6A methyltransferase component METTL14 in T cells

TX Lu, Z Zheng, L Zhang, HL Sun, M Bissonnette… - Cellular and Molecular …, 2020 - Elsevier
Background and aims Mouse models of colitis have been used to study the pathogenesis of
inflammatory bowel disease (IBD) and for pre-clinical development of therapeutic agents …

Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis

S Su, W Kong, J Zhang, X Wang, H Guo - Bioscience Reports, 2020 - portlandpress.com
Ulcerative colitis (UC) is a prevalent relapsing-remitting inflammatory bowel disease whose
pathogenetic mechanisms remain elusive. In the present study, colonic biopsies samples …

Identification of novel N7-methylguanine-related gene signatures associated with ulcerative colitis and the association with biological therapy

L Yang, L Yuan - Inflammation Research, 2023 - Springer
Objective Ulcerative colitis (UC) is an inflammatory disease characterized by recurrent
episodes of chronic intestinal inflammation. It is closely associated with immune …