The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

Abstract Impaired insulin/IGF-1 signaling (IIS) and caloric restriction (CR) prolong lifespan in
the nematode C. elegans. However, a cross comparison of these longevity pathways using a …

In this contribution, we describe a multi-omics systems biology study of the metabolic
changes that occur during aging in Caenorhabditis elegans. Sampling several time points …

Decline of cellular functions especially cognitive is a major deficit that arises with age in
humans. Harnessing the strengths of small and genetic tractable model systems has …

Dietary restriction (DR) is one of the most universal means of extending lifespan. Yet,
whether and how DR specifically affects the metabolic changes associated with aging is …

In Caenorhabditis elegans (C. elegans), ablation of germline stem cells (GSCs) leads to
infertility, which extends lifespan. It has been reported that aging and reproduction are both …

There are many mechanisms of lifespan extension, including the disruption of insulin/insulin-
like growth factor 1 (IGF-1) signaling, metabolism, translation, and feeding. Despite the …

Abstract Background Many Caenorhabditis elegans mutations increase longevity and much
evidence suggests that they do so at least partly via changes in metabolism. However, up …

Metabolism is intimately linked to aging. There is a growing number of studies showing that
endogenous metabolites may delay aging and improve healthspan. Through the analysis of …

Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and
nutritional framework is rapidly being uncovered, particularly using C. elegans as a model …