Background Mammalian aging is a highly complex process, a full mechanistic
understanding of which is still lacking. One way to help understand the molecular changes …

Aging is a complex process that can be characterized by functional and cognitive decline in
an individual. Aging can be assessed based on the functional capacity of vital organs and …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

By combining transcriptomic data with other data sources, inferences can be made about
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …

Background The biological mechanisms that underlie aging have not yet been fully
identified. Senescence, a phenomenon occurring in vitro, limits the number of cell divisions …

Organs and tissues age at different rates within a single individual. Such asynchrony in
aging has been widely observed at multiple levels, from functional hallmarks, such as …

Aging and age‐related pathology is a result of a still incompletely understood intricate web
of molecular and cellular processes. We present a C 57 BL/6 J female mice in vivo aging …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

Tissues within an organism and even cell types within a tissue can age with different
velocities. However, it is unclear whether cells of one type experience different aging …

To understand the changes in gene expression that occur as a result of age, which might
create a permissive or causal environment for age-related diseases, we produce a multi …