Epigenetics and colorectal cancer

VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

[HTML][HTML] Epigenetics and colorectal cancer pathogenesis

K Bardhan, K Liu - Cancers, 2013 - mdpi.com
Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation

F Coppedè - Cancer letters, 2014 - Elsevier
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Colorectal cancer: epigenetic alterations and their clinical implications

A Puccini, MD Berger, M Naseem, R Tokunaga… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular and clinical
features, which reflects the wide range of prognostic outcomes and treatment responses …

DNA methylation aberrancies delineate clinically distinct subsets of colorectal cancer and provide novel targets for epigenetic therapies

DJ Weisenberger, G Liang, HJ Lenz - Oncogene, 2018 - nature.com
Colorectal cancer (CRC) is a worldwide health concern with respect to both incidence and
mortality, and as a result, CRC tumorigenesis, progression and metastasis have been …

Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

DNA methylation markers in colorectal cancer

MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

[HTML][HTML] Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer

F Coppedè, A Lopomo, R Spisni… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Colorectal cancer epigenetics: complex simplicity

M Van Engeland, S Derks, KM Smits… - Journal of clinical …, 2011 - ascopubs.org
Colorectal cancer (CRC) has predominantly been considered a genetic disease,
characterized by sequential accumulation of genetic alterations. Growing evidence indicates …