Abstract Changes in DNA methylation, whether hypo‐or hypermethylation, have been
shown to be associated with the progression of colorectal cancer. Methylation changes …

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

Aim: Gain insight about the role of DNA methylation in the malignant growth of colon cancer.
Patients & methods: Methylation and gene expression from 90 adjacent-tumor paired tissues …

Cancer cells are characterized by a generalized disruption of the DNA methylation pattern
involving an overall decrease in the level of 5-methylcytosine together with regional …

Simple Summary Colorectal cancer is one of the most common neoplasia worldwide.
Metastasis in lymph nodes and distant organs indicates poor prognosis; However, the …

Background The development of colorectal cancer (CRC) is accompanied by extensive
epigenetic changes, including frequent regional hypermethylation particularly of gene …

Background We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes
to identify differentially methylated loci (DML) in colorectal carcinoma (CRC). Methods We …

Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as
a hallmark of cancer development and progression. However, locus-specific difference of …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

Aberrant DNA methylation occurs early in oncogenesis, is stable, and can be assayed in
tissues and body fluids. Therefore, genes with aberrant methylation can provide clues for …