This study has shown that IFN-α/β signaling is crucial for combating primary herpes simplex
virus type 2 (HSV-2) infection and for responding to immunotherapy using ligands to TLR3, 7 …

Interferon gamma (IFNγ) is important for immune resistance to herpes simplex virus (HSV)
infection. To examine the influence of IFNγ on the development of HSV-specific immune …

Toll-like receptors (TLRs) constitute a family of innate receptors that recognize and respond
to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa …

PROBLEM: To investigate the production of the CC chemokines RANTES, MCP‐1, and MIP‐
1α in the vaginal mucosa following HSV‐2 challenge in vaccinated and unvaccinated mice …

Using a hormonally induced susceptibility mouse model to investigate vaginal HSV type 2
(HSV-2) infection, a study was undertaken to determine the efficacy of a plasmid DNA …

The mouse model of genital herpes relies on medoxyprogesterone treatment of female mice
to render the vaginal lumen susceptible to inoculation with herpes simplex virus 2 (HSV-2) …

STUDY HYPOTHESIS Is it possible to immunologically activate human cervical epithelial
cells to produce antiviral factors that inhibit herpes simplex virus type 2 (HSV-2) replication …

Type I interferons (IFNs) present the first line of defense against viral infections, providing
antiviral, immunomodulatory and antiproliferative effects. The type I IFN family contains 12 …

The role of B, CD4+ T and CD8+ T cells in both primary genital infection with attenuated
herpes simplex virus type 2 (HSV-2) and development of protective immunity to a later …

Cell-mediated T-helper type-1 (Th1) responses play a vital role in the immunopathogenesis
of genital infections caused by herpes simplex virus 2 (HSV-2). We investigated the role of …