Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
A Nebel, R Kleindorp, A Caliebe, M Nothnagel… - Mechanisms of ageing …, 2011 - Elsevier
We conducted a case–control genome-wide association study (GWAS) of human longevity,
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity
In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the
common genetic variation in 16 genes recurrently regarded as candidates for human …
common genetic variation in 16 genes recurrently regarded as candidates for human …
Genetic associations for two biological age measures point to distinct aging phenotypes
Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
Genetic factors associated with longevity: a review of recent findings
AH Shadyab, AZ LaCroix - Ageing research reviews, 2015 - Elsevier
Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …
longevity and healthy aging is becoming increasingly important. Besides maintaining …