The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its
influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …

We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …

Background. Genome-wide association studies (GWAS) may yield insights into longevity.
Methods. We performed a meta-analysis of GWAS in Caucasians from four prospective …

Centenarians represent a rare phenotype appearing in roughly 10–20 per 100,000 persons
in most industrialized countries but as high as 40–50 per 100,000 persons in Okinawa …

The field of the “epidemiology of longevity” has been expanding rapidly in recent years.
Several long-term cohort studies have followed older adults long enough to identify the most …

Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …