Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …

Epigenetic clocks are calculated by combining DNA methylation states across select CpG
sites to estimate biologic age, and have been noted as the most successful markers of …

Aims Epigenetic clocks are widely applied as surrogates for biological age in different
tissues and/or diseases, including several neurodegenerative diseases. Despite white …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Background There is evidence that complex diseases and mortality are associated with DNA
methylation (DNAm) and age acceleration. Numerous epigenetic clocks, including Horvath …

Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …

The debate surrounding nature versus nurture remains a central question in neuroscience,
psychology, and in psychiatry, holding implications for both aging processes and the …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Epigenetic mechanisms such as DNA methylation have been implicated in a number of
diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative …

Background Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of
the central nervous system (CNS) characterized by irreversible disability at later progressive …