Cellular senescence can modulate various pathologies and is associated with irreparable
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …

Cellular senescence correlates with changes in the transcriptome. To obtain a complete
view on senescence-associated transcription networks and pathways, we assessed by deep …

Metabolomics is the latest state-of-the-art omics technology that provides a comprehensive
quantitative profile of metabolites. The metabolites are the cellular end products of metabolic …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

The dysregulation of cellular metabolism is a hallmark of ageing. To understand the
metabolic changes that occur as a consequence of the ageing process and to find …

Chronological age is an important predictor of morbidity and mortality; however, it is unable
to account for heterogeneity in the decline of physiological function and health with …

Understanding the complexity of aging is of utmost importance. This can now be addressed
by the novel and powerful approach of metabolomics. However, to date, only a few …

We analyzed an ex vivo model of in situ aged human dermal fibroblasts, obtained from 15
adult healthy donors from three different age groups using an unbiased quantitative …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …