Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies

E Cevenini, E Bellavista, P Tieri… - Current …, 2010 - ingentaconnect.com
Human aging and longevity are complex and multi-factorial traits that result from a
combination of environmental, genetic, epigenetic and stochastic factors, each contributing …

Integration of 'omics' data in aging research: from biomarkers to systems biology

J Zierer, C Menni, G Kastenmüller, TD Spector - Aging cell, 2015 - Wiley Online Library
Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

Signaling networks determining life span

CE Riera, C Merkwirth… - Annual review of …, 2016 - annualreviews.org
The health of an organism is orchestrated by a multitude of molecular and biochemical
networks responsible for ensuring homeostasis within cells and tissues. However, upon …

Systems biology in aging: linking the old and the young

L Hou, J Huang, CD Green, J Boyd-Kirkup… - Current …, 2012 - ingentaconnect.com
Aging can be defined as a process of progressive decline in the physiological capacity of an
organism, manifested by accumulated alteration and destabilization at the whole system …

[HTML][HTML] Towards AI-driven longevity research: an overview

N Marino, G Putignano, S Cappilli, E Chersoni… - Frontiers in …, 2023 - frontiersin.org
While in the past technology has mostly been utilized to store information about the
structural configuration of proteins and molecules for research and medical purposes …

A synopsis on aging—Theories, mechanisms and future prospects

JP da Costa, R Vitorino, GM Silva, C Vogel… - Ageing research …, 2016 - Elsevier
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Molecular mechanisms of aging and anti-aging strategies

Y Li, X Tian, J Luo, T Bao, S Wang, X Wu - Cell Communication and …, 2024 - Springer
Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

[PDF][PDF] Development and aging: Two opposite but complementary phenomena

BC Feltes, J de Faria Poloni… - Aging and Health-A …, 2015 - library.oapen.org
Aging is a consequence of an organism's evolution, where specific traits that lead to the
organism's development eventually promote aged phenotypes or could lead to age-related …

Key signaling pathways in aging and potential interventions for healthy aging

M Yu, H Zhang, B Wang, Y Zhang, X Zheng, B Shao… - Cells, 2021 - mdpi.com
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

A gerophysiology perspective on healthy ageing

PH Kemoun, I Ader, V Planat-Benard, C Dray… - Ageing research …, 2022 - Elsevier
Improvements in public health and health care have resulted in significant increases in
lifespan globally, but also in a significant increase in chronic disease prevalence. This has …