Immune system alterations during ageing are complex and pleiotropic, suggestive of
remodelling or altered regulation, rather than simple immune deficiency. The most dramatic …

In the elderly, many alterations of innate and acquired immunity have been described and
viewed as deleterious, hence the term immunosenescence. Immunosenescence is a …

In the classic sense, immunity is the ability of an organism to resist disease. On the one
hand, we must distinguish between age and disease; on the other hand, the interaction …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

Immunosenescence, the progressive decline in immune function that develops with age,
results from cumulative alterations in critical B-and T-cell subpopulations. Decreases in …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

Immune function declines with age, leading to increased infection and cancer rates in aged
individuals. In fact, recent progress in the study of immune ageing has introduced the idea …

Aging is associated clinically with increases in the frequency and severity of infectious
diseases and an increased incidence of cancer, chronic inflammatory disorders and …

With the improvement of medical care and hygienic conditions, there has been a
tremendous increment in human lifespan. However, many of the elderly (> 65 years) display …