Human brain-based models provide a powerful tool for the advancement of Parkinson's disease research and therapeutic development

SF McComish, AN MacMahon Copas… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease and
affects approximately 2–3% of the population over the age of 65. PD is characterised by the …

Animal Models of Parkinson's Disease: New models provide greater translational and predictive value

KM Gamber - Biotechniques, 2016 - Taylor & Francis
Parkinson's disease (PD) is a progressive neurodegenerative condition that results in
movement and cognitive disorders. PD arises from the degeneration of dopamine (DA) …

Classic and new animal models of Parkinson′ s disease

J Blesa, S Phani, V Jackson-Lewis… - BioMed Research …, 2012 - Wiley Online Library
Neurological disorders can be modeled in animals so as to recreate specific pathogenic
events and behavioral outcomes. Parkinson's Disease (PD) is the second most common …

Animal models of Parkinson's disease: An updated overview

P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

[HTML][HTML] Comprehensive perspectives on experimental models for Parkinson's disease

M Ke, CM Chong, Q Zhu, K Zhang, CZ Cai… - Aging and …, 2021 - ncbi.nlm.nih.gov
Parkinson's disease (PD) ranks second among the most common neurodegenerative
diseases, characterized by progressive and selective loss of dopaminergic neurons. Various …

Animal Models of Parkinson's Disease to Aid Drug Discovery and Development

KM Merchant, MF Chesselet, SC Hu, S Fahn - Animal and Translational …, 2008 - Elsevier
Publisher Summary Parkinson's Disease (PD) is the second most common, age-related
progressive neurodegenerative disorder. Two events have impacted significantly the …

Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson's disease

GR Choudhury, MM Daadi - PLoS One, 2018 - journals.plos.org
Parkinson's disease is a progressive neurodegenerative disease increasingly affecting our
aging population. Remarkable advances have been made in developing novel therapies to …

[HTML][HTML] From cell lines to pluripotent stem cells for modelling Parkinson's Disease

E Ferrari, A Cardinale, B Picconi, F Gardoni - Journal of Neuroscience …, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …

Experimental models of Parkinson's disease: Challenges and Opportunities

R Lal, K Chopra - European Journal of Pharmacology, 2024 - Elsevier
Parkinson's disease (PD) is a widespread neurodegenerative disorder occurs due to the
degradation of dopaminergic neurons present in the substantia nigra pars compacta (SNpc) …

[HTML][HTML] Animal models of Parkinson's disease: a gateway to therapeutics?

W Le, P Sayana, J Jankovic - Neurotherapeutics, 2014 - Elsevier
Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology,
although a complex interaction between environmental and genetic factors has been …