Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …

To evaluate molecular events associated with the aging process in animal models and
human tissues, microarray analysis is performed at the regional and cellular levels to define …

Ageing is linked to a number of changes in how the body and its organs function. On a
molecular level, ageing is associated with a reduction of telomere length, changes in …

The mechanistic causes of aging, the time-related decline in function and good health that
leads to increased mortality, remain poorly understood. Here we propose that age …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary
approaches to unravel its puzzles. To assist basic research on aging, we developed the …