Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …

The relationship between advanced age and immunologic deficits is becoming an area of
rapidly advancing research. Many of the clinical hurdles in the elderly population result from …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

A well-established feature of physiological ageing is altered immune function, a
phenomenon termed immunesenescence. Thought to be responsible in part for the …

The collective loss of immune protection during aging leads to poor vaccine responses and
an increased severity of infection for the elderly. Here, we review our current understanding …

The past decade has seen an explosion in research focusing on innate immunity. Through a
wide range of mechanisms including phagocytosis, intracellular killing and activation of …

With advancing age, the immune system undergoes changes that predispose to
autoimmune reactivity. Aging reduces the efficiency of physical barriers, decreasing …

The innate immune system is composed of a network of cells including neutrophils, NK and
NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions …