Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci

JL Buxton, M Suderman, JJ Pappas, N Borghol… - Scientific reports, 2014 - nature.com
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan and shorter
LTL is associated with increased risk of age-related disease. In this study we tested for …

Associations between global DNA methylation and telomere length in healthy adolescents

Y Dong, Y Huang, B Gutin, A Raed, Y Dong, H Zhu - Scientific reports, 2017 - nature.com
Emerging evidence suggests that epigenetics regulates telomere dynamics in adults.
However, the relationship between these pathways in children and youth remains unknown …

[HTML][HTML] Epigenome-wide association study of leukocyte telomere length

Y Lee, D Sun, APS Ori, AT Lu, A Seeboth… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Telomere length is associated with age-related diseases and is highly heritable. It is unclear,
however, to what extent epigenetic modifications are associated with leukocyte telomere …

[HTML][HTML] Leukocyte telomere length, T cell composition and DNA methylation age

BH Chen, CL Carty, M Kimura, JD Kark, W Chen… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with
chronological age. One measure of DNA methylation age-the extrinsic epigenetic age …

Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood

H Li, HT Hilmarsen, MB Hossain, J Björk… - Genes …, 2013 - Wiley Online Library
The frequency of chromosomal aberrations in peripheral blood predicts a probable cancer
risk. The individual telomere length and methylation of repetitive elements may be …

Telomere length and epigenetic clocks as markers of cellular aging: a comparative study

EE Pearce, R Alsaggaf, S Katta, C Dagnall, G Aubert… - Geroscience, 2022 - Springer
Telomere length (TL) and DNA methylation–based epigenetic clocks are markers of
biological age, but the relationship between the two is not fully understood. Here, we used …

Leukocyte telomere length variation due to DNA extraction method

J Denham, FZ Marques, FJ Charchar - BMC research notes, 2014 - Springer
Background Telomere length is indicative of biological age. Shorter telomeres have been
associated with several disease and health states. There are inconsistencies throughout the …

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance

J Lin, E Epel, J Cheon, C Kroenke, E Sinclair… - Journal of …, 2010 - Elsevier
Telomeres are the DNA–protein complexes that protect the ends of eukaryotic
chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding …

Systematic and cell type‐specific telomere length changes in subsets of lymphocytes

J Lin, J Cheon, R Brown, M Coccia… - Journal of …, 2016 - Wiley Online Library
Telomeres, the protective DNA‐protein complexes at the ends of linear chromosomes, are
important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) …

The individual blood cell telomere attrition rate is telomere length dependent

K Nordfjäll, U Svenson, KF Norrback, R Adolfsson… - PLoS …, 2009 - journals.plos.org
Age-associated telomere shortening is a well documented feature of peripheral blood cells
in human population studies, but it is not known to what extent these data can be transferred …