Shorter telomere length in Europeans than in Africans due to polygenetic adaptation

MEB Hansen, SC Hunt, RC Stone… - Human molecular …, 2016 - academic.oup.com
Leukocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a
complex genetic trait. Eleven SNPs have been shown in genome-wide association studies …

Cytomegalovirus infection reduces telomere length of the circulating T cell pool

PJEJ van de Berg, SJ Griffiths, SL Yong… - The Journal of …, 2010 - journals.aai.org
Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as
atherosclerosis, but the exact mechanisms generating variations in telomere length are …

Differing patterns of peripheral blood leukocyte telomere length in rheumatologic diseases

M Tamayo, A Mosquera, JI Rego… - Mutation Research …, 2010 - Elsevier
Telomeres progressively shorten with repeated somatic tissue cell division, their length
being an indicator of cellular ageing. Telomeric dysfunction may be implicated in a variety of …

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

J Deelen, M Beekman, V Codd… - International journal …, 2014 - academic.oup.com
Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL
has previously been associated with increased prospective mortality. However, it is not clear …

Paternal age is positively linked to telomere length of children

BM Unryn, LS Cook, KT Riabowol - Aging cell, 2005 - Wiley Online Library
Telomere length is linked to age‐associated diseases, with shorter telomeres in blood
associated with an increased probability of mortality from infection or heart disease. Little is …

[HTML][HTML] A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese

Y Liu, L Cao, Z Li, D Zhou, W Liu, Q Shen, Y Wu… - PloS one, 2014 - journals.plos.org
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related
diseases. We performed genome-wide association studies of mean LTL in 2632 individuals …

Telomere length measurement as a clinical biomarker of aging and disease

CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

[HTML][HTML] Telomeres and age-related diseases

HJ Gruber, MD Semeraro, W Renner, M Herrmann - Biomedicines, 2021 - mdpi.com
Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-
dimensional structure, they protect the coding DNA and ensure appropriate separation of …

[HTML][HTML] Telomere biology and age-related diseases

M Herrmann, I Pusceddu, W März… - Clinical Chemistry and …, 2018 - degruyter.com
Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?

JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …