PJEJ van de Berg, SJ Griffiths, SL Yong… - The Journal of …, 2010 - journals.aai.org
Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are …
M Tamayo, A Mosquera, JI Rego… - Mutation Research …, 2010 - Elsevier
Telomeres progressively shorten with repeated somatic tissue cell division, their length being an indicator of cellular ageing. Telomeric dysfunction may be implicated in a variety of …
Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL has previously been associated with increased prospective mortality. However, it is not clear …
Telomere length is linked to age‐associated diseases, with shorter telomeres in blood associated with an increased probability of mortality from infection or heart disease. Little is …
Y Liu, L Cao, Z Li, D Zhou, W Liu, Q Shen, Y Wu… - PloS one, 2014 - journals.plos.org
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related diseases. We performed genome-wide association studies of mean LTL in 2632 individuals …
CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related disease risk. There are several methods for studying blood telomere length (BTL) as a …
HJ Gruber, MD Semeraro, W Renner, M Herrmann - Biomedicines, 2021 - mdpi.com
Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3- dimensional structure, they protect the coding DNA and ensure appropriate separation of …
M Herrmann, I Pusceddu, W März… - Clinical Chemistry and …, 2018 - degruyter.com
Telomeres are the protective end caps of chromosomes and shorten with every cell division. Telomere length has been proposed as a biomarker of biological age and a risk factor for …
JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …