Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population

J Kozlitina, CK Garcia - PloS one, 2012 - journals.plos.org
Although mutations in the genes encoding either the protein or RNA component of
telomerase have been found in patients with various blood disorders, the impact of telomere …

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study

CM Martin‐Ruiz, J Gussekloo, D van Heemst… - Aging cell, 2005 - Wiley Online Library
Cross‐sectional studies have repeatedly suggested peripheral blood monocyte telomere
length as a biomarker of aging. To test this suggestion in a large population‐based follow …

Polygenic basis and biomedical consequences of telomere length variation

V Codd, Q Wang, E Allara, C Musicha, S Kaptoge… - Nature …, 2021 - nature.com
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …

[HTML][HTML] The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men

ES Epel, SS Merkin, R Cawthon, EH Blackburn… - Aging (Albany …, 2009 - ncbi.nlm.nih.gov
Telomere length (TL) has been proposed as a marker of mitotic cell age and as a general
index of human organismic aging. Short absolute leukocyte telomere length has been linked …

Telomere length is paternally inherited and is associated with parental lifespan

OT Njajou, RM Cawthon, CM Damcott… - Proceedings of the …, 2007 - National Acad Sciences
Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors
influencing this trait, we measured TL in a large homogeneous population, estimated the …

Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study

Z Huang, C Liu, Y Ruan, Y Guo, S Sun, Y Shi, F Wu - Geroscience, 2021 - Springer
It is well established from previous cross-sectional studies that telomeres shorten with age.
However, due to a considerable inter-individual variation in telomere length (TL), its …

The influence of alcohol consumption, cigarette smoking, and physical activity on leukocyte telomere length

L Latifovic, SD Peacock, TE Massey, WD King - … epidemiology, biomarkers & …, 2016 - AACR
Background: Telomeres protect from DNA degradation and maintain chromosomal stability.
Short telomeres have been associated with an increased risk of cancer at several sites …

Association between telomere length and heart disease in a narrow age cohort of older people

JM Starr, B McGurn, SE Harris, LJ Whalley… - Experimental …, 2007 - Elsevier
Telomere shortening is a feature of cellular ageing common to a range of human tissues.
Shorter telomeres are associated with an increased likelihood of mortality, including death …

Telomere length loss due to smoking and metabolic traits

J Huzen, LSM Wong… - Journal of internal …, 2014 - Wiley Online Library
Objectives Human age‐dependent telomere attrition and telomere shortening are
associated with several age‐associated diseases and poorer overall survival. The aim of …

Leukocyte telomere length in newborns: implications for the role of telomeres in human disease

P Factor-Litvak, E Susser, K Kezios, I McKeague… - …, 2016 - publications.aap.org
METHODS: LTL was measured in blood samples from 490 newborns and their parents.
RESULTS: LTL (mean±SD) was longer (9.50±0.70 kb) in newborns than in their mothers …