[HTML][HTML] Genetic variability in molecular pathways implicated in Alzheimer's disease: a comprehensive review

D Vogrinc, K Goričar, V Dolžan - Frontiers in aging neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant
part of the population. The majority of AD cases occur in the elderly with a typical age of …

[HTML][HTML] Alzheimer's disease genetics: from the bench to the clinic

CM Karch, C Cruchaga, AM Goate - Neuron, 2014 - cell.com
Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

[HTML][HTML] Genomics: new light on Alzheimer's disease research

YJ Jung, YH Kim, M Bhalla, SB Lee, J Seo - International journal of …, 2018 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents a
major cause of death in many countries. AD is characterized by profound memory loss …

Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology

G Tosto, C Reitz - Molecular and cellular probes, 2016 - Elsevier
Late-onset Alzheimer's disease (AD), the most common neurodegenerative disorder in
western countries, is clinically defined by progressive worsening in cognitive functions along …

Recent Insights into the Neurobiology of Alzheimer's Disease and Advanced Treatment Strategies

K Anitha, MK Singh, K Kohat, S Chenchula… - Molecular …, 2024 - Springer
In recent years, significant advancements have been made in understanding Alzheimer's
disease from both neurobiological and clinical perspectives. Exploring the complex systems …

[HTML][HTML] Advances in genetics and epigenetic alterations in Alzheimer's disease: a notion for therapeutic treatment

R Rabaneda-Bueno, B Mena-Montes, S Torres-Castro… - Genes, 2021 - mdpi.com
Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term
functional and cognitive impairment and greatly reduces life expectancy. Early genetic …

The genetics of Alzheimer's disease

MC Schu, R Sherva, LA Farrer, RC Green - … , Biological Diagnosis and …, 2012 - karger.com
As the most common form of dementia, Alzheimer's disease (AD) currently affects nearly 34
million people worldwide, with a prevalence of about 5.4 million cases in the United States …

Common and rare genetic variants associated with Alzheimer's disease

HE Marei, A Althani, J Suhonen… - Journal of Cellular …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing
increase of its incidence among aging populations, no effective cure has been developed …

[HTML][HTML] The genetic landscape of Alzheimer disease: clinical implications and perspectives

C Van Cauwenberghe, C Van Broeckhoven… - Genetics in …, 2016 - nature.com
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

The Genetic Basis of Alzheimer's Disease: Findings From Genome-Wide Studies

B Hooli, RE Tanzi - Genomics, Circuits, and Pathways in Clinical …, 2016 - Elsevier
Alzheimer's disease (AD) is the most common form of senile dementia, characterized by the
presymptomatic deposition of β-amyloid plaques followed by neurofibrillary tangles. After …