Antiaging therapies show promise in model organism research. Translation to humans is
needed to address the challenges of an aging global population. Interventions to slow …

Therapies to extend healthspan are poised to move from laboratory animal models to
human clinical trials. Translation from mouse to human will entail challenges, among them …

Background: To prevent onset of age-related diseases and physical and cognitive decline,
interventions to slow human aging and extend health span must eventually be applied to …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Aging is a modifiable risk factor for most chronic diseases and an inevitable process in
humans. The development of pharmacological interventions aimed at delaying or preventing …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Advances in understanding aging processes and their consequences are leading to the
development of therapies to slow or reverse adverse changes formerly considered to be" …

Recently, lifespan and healthspan have been extended in experimental animals using
interventions that are potentially translatable into humans. A great deal of thought and work …

The social and medical costs of the biological aging process are high and will rise rapidly in
coming decades, creating an enormous challenge to societies worldwide. In recent …

Life and health span have been extended in experimental animals using drugs that are
potentially translatable into humans. Considerable effort is needed beyond the usual steps …