RNAAgeCalc: A multi-tissue transcriptional age calculator
Biological aging reflects decline in physiological functions and is an effective indicator of
morbidity and mortality. Numerous epigenetic age calculators are available, however …
morbidity and mortality. Numerous epigenetic age calculators are available, however …
A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures
Accurately measuring biological age is crucial for improving healthcare for the elderly
population. However, the complexity of aging biology poses challenges in how to robustly …
population. However, the complexity of aging biology poses challenges in how to robustly …
Improved human age prediction by using gene expression profiles from multiple tissues
Studying transcriptome chronological change from tissues across the whole body can
provide valuable information for understanding aging and longevity. Although there has …
provide valuable information for understanding aging and longevity. Although there has …
Transcriptome analysis reveals the difference between “healthy” and “common” aging and their connection with age‐related diseases
A key goal of aging research was to understand mechanisms underlying healthy aging and
develop methods to promote the human healthspan. One approach is to identify gene …
develop methods to promote the human healthspan. One approach is to identify gene …
[HTML][HTML] Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues
D Palmer, F Fabris, A Doherty, AA Freitas… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
By combining transcriptomic data with other data sources, inferences can be made about
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …
A targeted epigenetic clock for the prediction of biological age
Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …
evidence indicates that they can also predict biological age. They are usually based on the …
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy
nature of gene expression changes with age, elucidating the transcriptional features of …
nature of gene expression changes with age, elucidating the transcriptional features of …
A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …