Background Early life stress (ELS) can compromise development, with higher amounts of
adversity linked to behavioral problems. To understand this linkage, a growing body of …

Relatively little is known about neurobiological changes attributable to early-life stressors
(eg, orphanage rearing), even though they have been associated with a heightened risk for …

Rationale The investigation of putative effects of early life stress (ELS) in humans on later
behavior and neurobiology is a fast developing field. While epidemiological and …

BackgroundChildhood early life stress (ELS) increases risk of adulthood major depressive
disorder (MDD) and is associated with altered brain structure and function. It is unclear …

There is a crisis of early childhood maltreatment in the United States. In 2012, the United
States Department of Health and Human Services noted 3.4 million referrals to childhood …

Previous studies of early life trauma suggest that in addition to its emotional impact,
exposure to early life stress (ELS) is associated with alterations in brain structure. However …

Background The experience of early life stress is a consistently identified risk factor for the
development of mood and anxiety disorders. Preclinical research employing animal models …

The early postnatal period is a highly sensitive time period for the developing brain, both in
humans and rodents. During this time window, exposure to adverse experiences can …

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical
health risks later in life. ELA has been associated with dysfunctional neurodevelopment …

A review of the human developmental neuroimaging literature that investigates outcomes
following exposure to psychosocial adversity is presented with a focus on two subcortical …