The cause of inflammatory bowel disease (IBD) is still unknown, but there is growing
evidence that environmental factors such as epigenetic changes can contribute to the …

Introduction Aberrant DNA methylation frequently occurs in the inflammatory mucosa in
ulcerative colitis (UC) and is involved in UC-related tumorigenesis. We performed …

Abstract Background and Aims The aim of this study was to investigate the genome-wide
DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the …

Background DNA methylation constitutes a key epigenetic mechanism by which cells
regulate gene transcription. Among its roles are the dynamic regulation of gene expression …

Background: Ulcerative colitis (UC) is an idiopathic disease of the large intestine with
evidence pointing to the role of epigenetic changes. Methods: Searches were performed in …

Abstract Background and Aims: Inflammatory bowel diseases (IBDs) are heterogeneous
disorders with complex aetiology. Quantitative genetic studies suggest that only a small …

Background Changes in the methylation status of inflammatory bowel disease (IBD)-
associated genes could significantly alter levels of gene expression, thereby contributing to …

Patients with inflammatory bowel disease (IBD) which includes ulcerative colitis (UC) and
Crohn's disease (CD) of the colon are at risk of developing colorectal cancer (CRC). Here …

Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal
cancer. Albeit the causes remain to be understood, epigenetic alterations have been …

DNA methylation has been implied to play a role in the immune dysfunction associated with
inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC) …