One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

Folate metabolism functions to supply one-carbon units that are vital for a range of
biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units …

Cells require one-carbon units for nucleotide synthesis, methylation and reductive
metabolism, and these pathways support the high proliferative rate of cancer cells. As such …

Highlights•Cellular metabolism is reprogrammed to support tumorigenesis.•Folate fulfill
many metabolic requirements of proliferating cells and relevant metabolic pathway affect …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Serine and glycine are biosynthetically linked, and together provide the essential precursors
for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth …

One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …

Abstract One-carbon (1C) metabolism encompasses folate-mediated 1C transfer reactions
and related processes, including nucleotide and amino acid biosynthesis, antioxidant …

Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has
long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered …