Alzheimer's disease due to loss of function: A new synthesis of the available data

KP Kepp - Progress in neurobiology, 2016 - Elsevier
Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

RJ Caselli, DS Knopman, G Bu - Alzheimer's & Dementia, 2020 - Wiley Online Library
Objective To reassess the role of amyloid beta (Aβ) and the amyloid precursor protein (APP)
system in the pathogenesis of Alzheimer's disease (AD). Background APP is a cell adhesion …

Metals, membranes, and amyloid-β oligomers: key pieces in the Alzheimer's disease puzzle?

AD Watt, VL Villemagne… - Journal of Alzheimer's …, 2012 - journals.sagepub.com
Over the past 100 years, there has been an exponential increase in our understanding of the
underlying pathology of Alzheimer's disease (AD). This growth in knowledge has largely …

Amyloid beta: the alternate hypothesis

H Lee, X Zhu, A Nunomura, G Perry… - Current Alzheimer …, 2006 - ingentaconnect.com
Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and
scientists are eager to decipher the underlying disease mechanism and, thereafter, target …

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

SW Pimplikar - The international journal of biochemistry & cell biology, 2009 - Elsevier
Since its inception, the amyloid cascade hypothesis has dominated the field of Alzheimer's
disease (AD) research and has provided the intellectual framework for therapeutic …

Amyloid β modification: a key to the sporadic Alzheimer's disease?

EP Barykin, VA Mitkevich, SA Kozin… - Frontiers in genetics, 2017 - frontiersin.org
Last year marked 25 years of research into the amyloid hypothesis of Alzheimer's disease
(AD)(Selkoe and Hardy, 2016). Over the last few years, studies on this subject have …

Ten challenges of the amyloid hypothesis of Alzheimer's disease

KP Kepp - Journal of Alzheimer's Disease, 2016 - journals.sagepub.com
The inability to effectively halt or cure Alzheimer's disease (AD), exacerbated by the recent
failures of high-profile clinical trials, emphasizes the urgent need to understand the complex …

β-Amyloid pathogenesis: Chemical properties versus cellular levels

MK Tiwari, KP Kepp - Alzheimer's & Dementia, 2016 - Elsevier
Although genetic Aβ variants cause early-onset Alzheimer's disease, literature reports on Aβ
properties are heterogeneous, obscuring molecular mechanisms, as illustrated by recent …

The amyloid hypothesis of Alzheimer's disease at 25 years

DJ Selkoe, J Hardy - EMBO molecular medicine, 2016 - embopress.org
Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches

B Van Broeck, C Van Broeckhoven… - Neurodegenerative …, 2007 - karger.com
During the last 10 years, a lot of progress has been made in unraveling the pathogenic
cascade leading to Alzheimer disease (AD). According to the most widely accepted …