Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

Objective To reassess the role of amyloid beta (Aβ) and the amyloid precursor protein (APP)
system in the pathogenesis of Alzheimer's disease (AD). Background APP is a cell adhesion …

Over the past 100 years, there has been an exponential increase in our understanding of the
underlying pathology of Alzheimer's disease (AD). This growth in knowledge has largely …

Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and
scientists are eager to decipher the underlying disease mechanism and, thereafter, target …

Since its inception, the amyloid cascade hypothesis has dominated the field of Alzheimer's
disease (AD) research and has provided the intellectual framework for therapeutic …

Last year marked 25 years of research into the amyloid hypothesis of Alzheimer's disease
(AD)(Selkoe and Hardy, 2016). Over the last few years, studies on this subject have …

The inability to effectively halt or cure Alzheimer's disease (AD), exacerbated by the recent
failures of high-profile clinical trials, emphasizes the urgent need to understand the complex …

Although genetic Aβ variants cause early-onset Alzheimer's disease, literature reports on Aβ
properties are heterogeneous, obscuring molecular mechanisms, as illustrated by recent …

Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

During the last 10 years, a lot of progress has been made in unraveling the pathogenic
cascade leading to Alzheimer disease (AD). According to the most widely accepted …