The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of …

Alzheimer's disease and other neurodegenerative disorders of aging are characterized by
clinical and pathological features that are relatively specific to humans. To obtain greater …

The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …

Gene expression studies suggest that aging of the human brain is determined by a complex
interplay of molecular events, although both its region-and cell-type-specific consequences …

Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …

Aging brains undergo cognitive decline, associated with decreased neuronal synapse
number and function and altered metabolism. Astrocytes regulate neuronal synapse …

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …

The hippocampus plays a crucial role in learning and memory, and its progressive
deterioration with age is functionally linked to a variety of human neurodegenerative …