Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

A global DNA hypomethylation and local changes in the methylation levels of specific DNA
loci occur during aging in mammals. Global hypomethylation mainly affects highly …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …