Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …