Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenetic changes during ageing and their underlying mechanisms
DL Braga, F Mousovich-Neto, G Tonon-da-Silva… - Biogerontology, 2020 - Springer
As life expectancy increases worldwide, ageing and age-related diseases arise as a major
issue for societies around the globe. Understanding the biological mechanisms underlying …
issue for societies around the globe. Understanding the biological mechanisms underlying …
DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …
their potential in predicting healthspan and application in age-related illnesses, such as …
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
The DNA methylome as a biomarker for epigenetic instability and human aging
AR Mendelsohn, JW Larrick - Rejuvenation research, 2013 - liebertpub.com
Methylation of DNA is intimately involved in control of mammalian/vertebrate gene
expression as part of a complex epigenetic regulatory system. We hypothesize that DNA …
expression as part of a complex epigenetic regulatory system. We hypothesize that DNA …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
Background Epigenetic clocks have been recognized for their precise prediction of
chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks …
chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks …
[HTML][HTML] Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites,
which can accurately measure chronological age in different species. Recently, several …
which can accurately measure chronological age in different species. Recently, several …
DNA methylation as a biomarker of aging in epidemiologic studies
Cancer is largely an aging disease. Accelerated biological aging may be the strongest
predictor of cancer and other chronic disease risks. In the absence of reliable and …
predictor of cancer and other chronic disease risks. In the absence of reliable and …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …