Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

In addition to promoting various forms of cell death, most conventional anti-tumor therapies
also promote senescence. There is now extensive evidence that therapy-induced …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in
response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is a permanent growth arrest in cells with damage or stress that could
lead to transformation. Some tumor cells also undergo senescence in response to …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Therapy-induced cellular senescence is a state of stable growth arrest induced by common
cancer treatments such as chemotherapy and radiation. In an oncogenic context, therapy …