Long‐term variability of inflammatory markers and associated factors in a population‐based cohort

SD Nash, KJ Cruickshanks, R Klein… - Journal of the …, 2013 - Wiley Online Library
Objectives To investigate long‐term variability in serum high‐sensitivity C‐reactive protein
(CRP) and interleukin‐6 (IL‐6) and to determine associated risk factors for high‐risk …

Three‐year change in inflammatory markers in elderly people and mortality: The Invecchiare in Chianti Study

DE Alley, E Crimmins… - Journal of the …, 2007 - Wiley Online Library
OBJECTIVES: To describe changes in interleukin‐6 (IL‐6) and C‐reactive protein (CRP)
and to determine how changes are related to mortality in elderly people. DESIGN …

Long‐term systemic inflammation and cognitive impairment in a population‐based cohort

MA Wichmann, KJ Cruickshanks… - Journal of the …, 2014 - Wiley Online Library
Objectives Evidence suggests inflammation is associated with cognitive impairment, but
previous epidemiological studies have reported conflicting results. Design Prospective …

Interleukin‐6, C‐reactive protein, and tumor necrosis factor‐alpha as predictors of mortality in frail, community‐living elderly individuals

S Giovannini, G Onder, R Liperoti… - Journal of the …, 2011 - Wiley Online Library
OBJECTIVES: To investigate whether interleukin‐6 (IL‐6), C‐reactive protein (CRP) and
tumor necrosis factor‐alpha (TNF‐α) protein levels predict all‐cause mortality in older …

Inflammatory biomarkers as predictors of hospitalization and death in community-dwelling older adults

AH Salanitro, CS Ritchie, M Hovater, DL Roth… - Archives of gerontology …, 2012 - Elsevier
Individuals with multimorbidity may be at increased risk of hospitalization and death.
Comorbidity indexes do not capture severity of illness or healthcare utilization; however …

Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars

NS Jenny, B French, AM Arnold… - … Series A: Biomedical …, 2012 - academic.oup.com
Background. Associations of inflammation with age-related pathologies are documented;
however, it is not understood how changes in inflammation over time impact healthy aging …

Predictors of interleukin‐6 elevation in older adults

S Zhu, KV Patel, S Bandinelli, L Ferrucci… - Journal of the …, 2009 - Wiley Online Library
OBJECTIVES: To investigate the characteristics of older adults who develop high interleukin‐
6 (IL‐6) levels at 3‐year follow‐up. DESIGN: Population‐based study of adults living in …

Chronic inflammation as a determinant of future aging phenotypes

TN Akbaraly, M Hamer, JE Ferrie, G Lowe, GD Batty… - Cmaj, 2013 - Can Med Assoc
Background: The importance of chronic inflammation as a determinant of aging phenotypes
may have been underestimated in previous studies that used a single measurement of …

Peripheral blood markers of inflammation predict mortality and functional decline in high‐functioning community‐dwelling older persons

DB Reuben, AI Cheh, TB Harris… - Journal of the …, 2002 - Wiley Online Library
OBJECTIVES: Several peripheral blood markers of inflammation have demonstrated
prognostic ability, but the value of combining multiple markers as a measure of inflammatory …

Inflammatory markers in population studies of aging

T Singh, AB Newman - Ageing research reviews, 2011 - Elsevier
PURPOSE: To review findings from major epidemiologic studies regarding risk factors for
and consequences of elevated markers of inflammation in older adults. RESULTS: Most …