With the prolonged lifespan brought about by medical advances, attention is increasingly
focused on problems that arise from such longevity, including diseases that tend to occur in …

The gradual decline of cognitive ability with age, even in the absence of overt brain disease,
is a growing problem. Although cognitive aging is a common and feared accompaniment of …

With the population of older adults expected to grow rapidly over the next two decades, it
has become increasingly important to advance research efforts to elucidate the mechanisms …

Normal cognitive and brain aging are a set of interconnected and complex biological
phenomena that can be understood from a multidisciplinary and integrative approach …

While aging is associated with modest declines in certain aspects of cognitive function
(memory, executive function, processing speed), many cognitive domains can remain …

Research during the last two decades has shown that the brain undergoes continuous
changes throughout life, with substantial heterogeneity in age trajectories between regions …

New discoveries challenge the long-held view that aging is characterized by progressive
loss and decline. Evidence for functional reorganization, compensation and effective …

The last three decades produced a striking increase in investigations of the neurobiological
basis of brain aging and aging-related changes in neural and cognitive function …

Aging in the absence of neurodegenerative disease is frequently accompanied by deficits in
memory and other cognitive capacities. Although relatively modest in severity, these …

The underlying premise of current theories of cognitive decline with age tend to be primarily
cognitive or biological explanations, with relatively few theories adequately integrating both …