[HTML][HTML] The epigenetic clock: a molecular crystal ball for human aging?
Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …
Back to the future: epigenetic clock plasticity towards healthy aging
K Declerck, WV Berghe - Mechanisms of ageing and development, 2018 - Elsevier
Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
Epigenetic clock: a promising mirror of ageing
Z Liu, Y Zhu - The Lancet Healthy Longevity, 2021 - thelancet.com
Ageing is one of the major risk factors for many chronic diseases. One key point that needs
to be addressed to address ageing-related issues is to precisely quantify individual ageing …
to be addressed to address ageing-related issues is to precisely quantify individual ageing …
Assessment of epigenetic clocks as biomarkers of aging in basic and population research
ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
[HTML][HTML] The epigenetic landscape of age-related diseases: the geroscience perspective
In this review, we summarize current knowledge regarding the epigenetics of age-related
diseases, focusing on those studies that have described DNA methylation landscape in …
diseases, focusing on those studies that have described DNA methylation landscape in …
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
The aging process is characterized by the presence of high interindividual variation between
individuals of the same chronical age prompting a search for biomarkers that capture this …
individuals of the same chronical age prompting a search for biomarkers that capture this …
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging
Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …
models using DNA methylation data can create “epigenetic clocks” which are proposed to …