Longevity is an extremely complex phenotype that is determined by environment, life style
and genetics. Genome wide association studies (GWAS) have been a powerful tool to …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

Complex diseases are major contributors to human mortality in old age. Paradoxically, many
genetic variants that have been associated with increased risks of such diseases are found …

Understanding the genetic basis of human longevity remains a challenge but could lead to
life-extending interventions and better treatments for age-related diseases. Toward this end …

Genetic factors contribute to human aging and longevity through the modulation of biologic
pathways, but few longevity-gene associations have been replicated to date. Participants in …

Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …