Identification of the mitophagy-related diagnostic biomarkers in hepatocellular carcinoma based on machine learning algorithm and construction of prognostic model

D Tu, J Cao, J Zhou, B Su, S Wang, G Jiang… - Frontiers in …, 2023 - frontiersin.org
Background and aims As a result of increasing numbers of studies most recently, mitophagy
plays a vital function in the genesis of cancer. However, research on the predictive potential …

MCT4 as a potential therapeutic target to augment gemcitabine chemosensitivity in resected pancreatic cancer

SH Lee, HK Hwang, WJ Lee, CM Kang - Cellular Oncology, 2021 - Springer
Background Pancreatic cancer is a devastating disease with a high relapse rate, even in
case of resectable pancreatic cancer. Here, we aimed to identify the prognostic significance …

A mitophagy-related gene signature associated with prognosis and immune microenvironment in colorectal cancer

C Zhang, C Zeng, S Xiong, Z Zhao, G Wu - Scientific reports, 2022 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease and one of the most prevalent
malignancies worldwide. Previous research has demonstrated that mitophagy is crucial to …

Mitophagy in carcinogenesis and tumour progression-A new paradigm with emerging importance

SK Ray, S Mukherjee - Anti-Cancer Agents in Medicinal …, 2021 - ingentaconnect.com
The term Mitophagy has been newly concerned in reforming the metabolic landscape inside
cancerous cells in addition to the interface between malignant cells as well as other major …

The match between molecular subtypes, histology and microenvironment of pancreatic cancer and its relevance for chemoresistance

J Martinez-Useros, M Martin-Galan, J Garcia-Foncillas - Cancers, 2021 - mdpi.com
Simple Summary Based on the four molecular subtypes of pancreatic cancer described by
Bailey et al. 2016, in the present article we match the molecular, histology and …

Identification of a chemoresistance-related prognostic gene signature by comprehensive analysis and experimental validation in pancreatic cancer

J Chen, Z Liu, Z Wu, W Li, X Tan - Frontiers in Oncology, 2023 - frontiersin.org
Background Chemoresistance is a major hurdle to improving the prognosis of pancreatic
cancer (PC). This study aimed to identify key genes regulating chemoresistance and …

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

DP Panigrahi, PP Praharaj, CS Bhol… - Seminars in cancer …, 2020 - Elsevier
Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …

Mitophagy: A novel perspective for insighting into cancer and cancer treatment

C Song, S Pan, J Zhang, N Li, Q Geng - Cell Proliferation, 2022 - Wiley Online Library
Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma

J Li, J Yin, W Li, H Wang, B Ni - Cancer Cell International, 2023 - Springer
Background Multiple molecular subtypes with distinct clinical outcomes in pancreatic
adenocarcinoma (PAAD) have been identified in recent years. Cuproptosis is a new form of …

A metabolism-relevant signature as a predictor for prognosis and therapeutic response in pancreatic cancer

Q Chen, N Pu, H Yin, J Zhang, G Zhao… - Experimental …, 2022 - journals.sagepub.com
Although several altered metabolic genes have been identified to be involved in the
tumorigenesis and advance of pancreatic cancer (PC), their prognostic values remained …