Senescence and apoptosis: dueling or complementary cell fates?

BG Childs, DJ Baker, JL Kirkland, J Campisi… - EMBO …, 2014 - embopress.org
In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

Context-dependent effects of cellular senescence in cancer development

P Lecot, F Alimirah, PY Desprez, J Campisi… - British journal of …, 2016 - nature.com
Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

[HTML][HTML] Senescence and tumor suppression

P Hinds, J Pietruska - F1000Research, 2017 - ncbi.nlm.nih.gov
Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Pro-and anti-tumorigenic functions of the senescence-associated secretory phenotype

L Lau, G David - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Unmasking senescence: context-dependent effects of SASP in cancer

DV Faget, Q Ren, SA Stewart - Nature Reviews Cancer, 2019 - nature.com
Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Cellular senescence and its effector programs

R Salama, M Sadaie, M Hoare… - Genes & …, 2014 - genesdev.cshlp.org
Cellular senescence is a stress response that accompanies stable exit from the cell cycle.
Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways …

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

B Ritschka, M Storer, A Mas, F Heinzmann… - Genes & …, 2017 - genesdev.cshlp.org
Senescence is a form of cell cycle arrest induced by stress such as DNA damage and
oncogenes. However, while arrested, senescent cells secrete a variety of proteins …

The senescence-associated secretory phenotype: the dark side of tumor suppression

JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …

Cellular senescence: the sought or the unwanted?

Y Sun, JP Coppé, EWF Lam - Trends in Molecular Medicine, 2018 - cell.com
Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …

The role of cellular senescence and SASP in tumour microenvironment

M Takasugi, Y Yoshida, E Hara, N Ohtani - The FEBS journal, 2023 - Wiley Online Library
Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …