The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

Immune aging is a complex process rendering the host susceptible to cancer, infection, and
insufficient tissue repair. Many autoimmune diseases preferentially occur during the second …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Human immunosenescence contributes to morbidity and mortality in later life. The age-
associated increasing incidence ofcancer and cardiovascular disease plateaus at around 80 …

Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …

The immunologic theory of aging, proposed more than 40 years ago by Roy Walford,
suggests that the normal process of aging in man and in animals is pathogenetically related …

The incidence of most common cancers increases with age. This occurs in association with,
and is possibly caused by a decline in immune function, termed immune senescence …