The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to …
S Le Saux, CM Weyand… - Annals of the New York …, 2012 - Wiley Online Library
With increasing age, the ability of the adaptive immune system to respond to vaccines and to protect from infection declines. In parallel, the production of inflammatory mediators …
K Dorshkind, S Swain - Current opinion in immunology, 2009 - ncbi.nlm.nih.gov
Understanding why we age and how that process can be delayed or reversed are topics that have engaged both researchers and the general public [1]. From a scientific perspective …
Immunosenescence, describing alterations, including decline of immune responses with age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
Immunosenescence contributes to a decreased capacity of the immune system to respond effectively to infections or vaccines in the elderly. The full extent of the biological changes …
J Hazeldine, JM Lord - Biogerontology, 2015 - Springer
A well-established feature of physiological ageing is altered immune function, a phenomenon termed immunesenescence. Thought to be responsible in part for the …
R Kumar, EA Burns - Expert review of vaccines, 2008 - Taylor & Francis
Aging is associated with declines in immune system function, or 'immunosenescence', leading to progressive deterioration in both innate and adaptive immunity. These changes …
G Del Giudice, JJ Goronzy… - npj Aging and …, 2017 - nature.com
The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new …
JE McElhaney, RB Effros - Current opinion in immunology, 2009 - Elsevier
The most profound consequences of immune senescence with respect to human health are the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …